Vol. I · No. 199WED, NOV 4, 2026
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Efficient MoE Training for Biological Foundation Models

As language models grow, scaling dense architectures becomes increasingly expensive. In a dense transformer, every token passes through every layer, so adding... As language models grow, scaling dense architectures becomes increasingly expensive. In a dense transformer, every token passes through every layer, so adding capabilities increases computation for both training and inference. Mixture-of-experts (MoE) architectures take a different approach to scaling by using many subnetworks, or experts, while activating only a small subset for each token. Source

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Dense vs. MoE Models: Active Parameters, Throughput, and When to Choose Each

How can a 30B-parameter model activate only 3B parameters per token, and still use the capacity of the larger model? Nemotron 3.5 Lightning illustrates the... How can a 30B-parameter model activate only 3B parameters per token, and still use the capacity of the larger model? Nemotron 3.5 Lightning illustrates the answer: It uses a Mixture-of-Experts (MoE) architecture that selects only a subset of its parameters for each token. There are two dominant model architectures: Dense model and MoE. How a model organizes its parameters matters as much as… Source

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When to Use Encode-Prefill-Decode Disaggregation to Accelerate Multimodal Model Serving

Encode-prefill-decode (EPD) disaggregation is an inference optimization technique for multimodal models that separates the vision encoder stage from the prefill... Encode-prefill-decode (EPD) disaggregation is an inference optimization technique for multimodal models that separates the vision encoder stage from the prefill and decode stages. It is most effective for image-heavy prompts, short-to-medium outputs, and quantized mixture-of-experts (MoE) models. This post shows when and how to use EPD disaggregation with NVIDIA Dynamo to achieve up to 5x… Source

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ACE: Adaptive Calibration-Free Expert Skipping for MoE-based LLMs

Mixture-of-Experts (MoE) architectures provide an efficient paradigm for scaling large language models (LLMs), yet fixed top-k routing activates the same number of expert slots for every token, causing substantial redundant computation. Existing expert-skipping methods often rely on router confidence, calibration data, or additional training, and therefore cannot reliably estimate the actual contribution of routed experts. To this end, we propose ACE, a training-free, calibration-free, and checkpoint-preserving framework for token-adaptive expert skipping in MoE-based LLMs. ACE contains two c...

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Experiment with Qwen3.8-Flash-Next on NVIDIA GB300 NVL72 for Agentic Coding

Alibaba released the model weights for Qwen3.8-Flash-Next as a preview of the upcoming Qwen4 architecture for developers to experiment with and evaluate. It’s... Alibaba released the model weights for Qwen3.8-Flash-Next as a preview of the upcoming Qwen4 architecture for developers to experiment with and evaluate. It’s a multimodal mixture-of-experts (MoE) model with a 125B-parameter main model supplemented by an additional 51B N-gram embeddings, with 6B parameters activated per token. It has a native 262,144-token context window, extensible to 1M tokens… Source

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Routing Divergence Is Not Evidence of Behavioral Influence in Same-Weight MoE Self-Distillation

Two Mixture-of-Experts (MoE) forward passes can share every weight yet route the same token through different experts. This creates a possible blind spot in same-weight self-distillation, where a demonstration-conditioned teacher supervises a query-only student. We study this mismatch in its single-step form, with frozen weights rather than as a proxy for a full training trajectory. An exact blockwise decomposition separates a routing term, which changes gates at fixed content, from a dense-like content term. Across seven open-weight checkpoints and two domains, the routing term spans only $1...

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THESIS-MoE: Trainable Hierarchical Extraction and SteerIng of Sycophancy in Mixture-of-Experts

Sycophancy, the tendency of a language model to change its answer to match a user's stated belief, is a common alignment failure. Existing activation steering methods typically apply a single contrastive direction uniformly throughout the model, which is an unconditional intervention that alters activations even when no sycophantic behavior is present, trading knowledge retention for behavioral correction. In Mixture-of-Experts (MoE) models, prior work further suggests that behavior is encoded within expert computations rather than routing decisions alone, making precise behavioral steering p...

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DeaMoE: Efficient MoE Structure for Fast Small-Batch Decoding

Mixture-of-Experts (MoE) models have been widely adopted in real-time interactive applications such as coding assistants, real-time audio-video interaction systems. To meet the extremely low response latency requirements of these scenarios, practitioners commonly employ small-batch decoding, under which MoE inference becomes memory-bound and is severely bottlenecked by expert weight loading. However, this bottleneck has received limited attention, and existing solutions such as post-training weight compression or fine-grained expert design during pre-training either degrade model accuracy or ...

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Regime-Gated Residual Mixture-of-Experts for Cross-Sectional Volatility Forecasting

Financial volatility is regime dependent, yet incorporating regime information into neural networks can also destabilize training. This paper asks where such information should enter a neural cross-sectional volatility forecasting model. We study five-day realized-volatility forecasts for 1,027 U.S. equities using a rolling walk-forward evaluation framework in which information, model capacity, hyperparameter tuning, and random seeds are matched across architectures. We propose RG-ResMoE, a regime-gated residual mixture-of-experts architecture in which regime information is used only for expe...

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NVIDIA Nemotron 3.5 Lightning Delivers Fast, Accurate Specialized Task Execution for Long-Running Agents

Long-running AI agents spend most of their time on high-volume execution: tool calls, result validation, and subagent delegation. Using a frontier reasoning... Long-running AI agents spend most of their time on high-volume execution: tool calls, result validation, and subagent delegation. Using a frontier reasoning model for every execution step adds cost and latency. NVIDIA Nemotron 3.5 Lightning is an open 30B mixture-of-experts (MoE) model with 3B active parameters built for that execution layer of always-on agents. It is designed for harnesses… Source

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Disentangling Co-Occurring Retinal Pathologies with Saliency-Guided Sparse Expert Routing

Retinal fundus images frequently exhibit multiple co-occurring pathologies, yet standard deep learning classifiers apply static, identical computation to every image regardless of the underlying disease distribution. We propose a novel architecture that resolves this via sparse conditional computation, pairing a Guided Context Gating (GCG) spatial attention front-end with a sparsely-routed Mixture-of-Experts (MoE) block operating over feature tokens. Crucially, this routing yields an interpretable, data-driven decomposition. Expert allocation is significantly disease-dependent (p < 0.001), wi...

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