Vol. I · No. 98SUN, JUL 26, 2026
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Knowledge- and Gradient-Guided Reinforcement Learning for Parametrized Action Markov Decision Processes

In this paper, we study Reinforcement Learning in Parametrized Action Markov Decision Processes (PAMDP), where each decision consists of a symbolic action and numerical parameters. In such settings Reinforcement Learning algorithms typically determine parameters with one-shot estimators, which makes their training sample inefficient. Though in most PAMDP environments explicit but incomplete knowledge (e.g., rules, safety constraints, or expert heuristics) is available, it is rarely directly used to increase the sample-efficiency of training Reinforcement Learning agents. We step into this gap...

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Accelerating End-to-End Co-Folding Performance with NVIDIA BioNeMo Agent Toolkit

Biomolecular structure prediction and co-folding with models like OpenFold3 are now mainstream, large-scale workloads powering drug discovery and protein... Biomolecular structure prediction and co-folding with models like OpenFold3 are now mainstream, large-scale workloads powering drug discovery and protein design. Increasingly, they’re driven end-to-end by AI agents. For an agent to run that pipeline well, every step needs to be fast and scalable: Multiple Sequence Alignment (MSA) generation, co-folding inference, serving, and multi-GPU scale-out. Source

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Running Low-Latency Analytical Workloads with GPU-Accelerated Presto on NVIDIA GB200 NVL72

Presto is an open source, distributed SQL engine for running fast, interactive queries on very large datasets. On NVIDIA GPUs, Presto delivers peak performance... Presto is an open source, distributed SQL engine for running fast, interactive queries on very large datasets. On NVIDIA GPUs, Presto delivers peak performance for analytical query workloads and provides low latency for users and agents. GPU-accelerated Presto brings low latency to your analytical workloads, keeping you and your agents unblocked and iterating as fast as possible. Source

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Create a LangChain Deep Agents Harness Profile for NVIDIA Nemotron 3 Ultra to Improve Performance

Agentic systems often face a trade-off between accuracy and cost. The highest-performing proprietary frontier models and harnesses provide top accuracy but are... Agentic systems often face a trade-off between accuracy and cost. The highest-performing proprietary frontier models and harnesses provide top accuracy but are expensive. Fine-tuning offers one way to address this problem. Smaller or more efficient open models starting with lower accuracy are taught to perform better with specific agents. However, fine-tuning requires expertise and hardware for… Source

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